. Lectures on surgical pathology : delivered at the Royal College of Surgeons of England. or pasty fluid that may be pressed frommelanotic cancers, the greater part of the microscopic structures aresuch as might belong to an uncolored medullary cancer. It is oftenremarkable by how small a proportion of pigment the deepest blackcolor may be given to the mass : a hundredth part of the constituentstructures may suffice. The pigment is generally in granules or mole-cules : but it is sometimes in nuclei or in corpuscles like them. The majority of the pigment-granules are minute particles, not muchu

. Lectures on surgical pathology : delivered at the Royal College of Surgeons of England. or pasty fluid that may be pressed frommelanotic cancers, the greater part of the microscopic structures aresuch as might belong to an uncolored medullary cancer. It is oftenremarkable by how small a proportion of pigment the deepest blackcolor may be given to the mass : a hundredth part of the constituentstructures may suffice. The pigment is generally in granules or mole-cules : but it is sometimes in nuclei or in corpuscles like them. The majority of the pigment-granules are minute particles, not muchu Stock Photo
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. Lectures on surgical pathology : delivered at the Royal College of Surgeons of England. or pasty fluid that may be pressed frommelanotic cancers, the greater part of the microscopic structures aresuch as might belong to an uncolored medullary cancer. It is oftenremarkable by how small a proportion of pigment the deepest blackcolor may be given to the mass : a hundredth part of the constituentstructures may suffice. The pigment is generally in granules or mole-cules : but it is sometimes in nuclei or in corpuscles like them. The majority of the pigment-granules are minute particles, not muchunlike those of the pigment-cells of the choroid membrane. When outof focus, they appear black or deep brown; but, when in focus, theyhave pellucid centres, with broad black borders. They appear spheri-cal ; and usually the majority of them are free, i. e., not inclosed incells, and vibrate with molecular movement in the fluid that suspendsthem. The greater part of the. color depends on these free granules(Fig. 107); but others like them are inclosed in the cancer-cells, or, Fig. 107.*. more rarely, in nuclei. Sometimes those in the cells are clusteredaround the nucleus ; sometimes they are irregularly scattered ; in eithercase, they appear as if gradually increasing till they fill the cell, andchange it into a granule-mass, which, but for its color, we might exactlycompare with the granule-masses of fatty degeneration. While thepigment-granules are thus collecting, the nucleus remains clear ; but atlast, when the cell appears like a granule-mass, it is lost sight of.After this, moreover, the masses formed of pigment-granules maybreak up, and add their granules to those which we may suppose tohave been free from their first formation. The completely melanoticcells and their corpuscles, seen singly in the microscope, look not black, but rusty brown or pale umber-brown : like blood-cells, it is only whenamassed that they give the full tint of color. With the melanotic granules, the